It was demonstrated that the expression of p-PI3K, p-Akt, and p-mTOR was significantly reduced in A375 cells after PPI treatment, and inhibited melanoma cell proliferation and enhanced melanoma cell apoptosis by suppressing PI3K/Akt/mTOR signaling pathway, which blocked melanoma cells at G0/G1 stage, thus reducing melanoma progression. Here, AKT1 is linked to melanoma.