The expression of FAK/PI3K/Akt/mTOR signaling-related proteins, including Akt, p-Akt, PI3K, p-PI3K, mTOR, p-mTOR, and FAK, was reduced in cis-4-hydroxycinnamate treated melanoma cells, which inhibited the metastasis of human melanoma cells through the FAK/PI3K/Akt/mTOR signaling pathway (Yang et al., 2018a). This evidence concerns the gene AKT1 and melanoma.