It was shown that the phosphorylation levels of PI3K, P-AKT, P-mTOR, and P-p7036k1 were reduced in melanoma A375, MV3, and M14 cells treated with TanIIA, which inhibited the proliferation and invasion, and migration ability of melanoma cells, and promoted the autophagosome production of A375, In addition, TanIIA inhibits the development of A375 melanoma-induced tumor weight and volume in mice (Li et al., 2017). This evidence concerns the gene MTOR and melanoma.