A meta-analysis conducted for the USPSTF, which aggregated data from 10 studies that adjusted for all seven Framingham risk factors, found a summary estimate of relative risk for incident coronary heart disease to be 1.58 (95 % CI, 1.37 to 1.83) for C-reactive protein (CRP) levels greater than 3.0 mg/L compared to levels less than 1.0 mg/L in patients without pre-existing cardiovascular disease [25]. This evidence concerns the gene CRP and cardiovascular disorder.