CRP and diabetes mellitus: In addition, there was a high risk primary prevention cohort that consisted of male patients at least 50 years old and female patients at least 60 years old if they had either a history of diabetes, CKD, or peripheral vascular disease and also one of the following risk factors: asymptomatic coronary stenosis on cardiac imaging, smoking history, HDL < 40 mg/dL, hs-CRP > 2.0 mg/L, Lp(a) of > 50 mg/dL, microalbuminuria, or history of familial hypercholesterolemia (age cutoff decreased at least 35 years for men and 45 years for women with FH).