In the Third National Health and Nutrition Examination Survey, the prevalence of high (> 3 mg/L) hs-CRP levels was significantly greater in patients with risk factors that increase risk of ASCVD including obesity (46.6 %), hypertension (38.8 %), diabetes (52.1 %), smoking history (27.2 %), female gender (31.0 %) or black ethnicity (34.9 %) (P < 0.001 for all compared to absence of characteristic) [26]. The gene discussed is CRP; the disease is atherosclerosis.