Inactivation of GPX4 or SLC7A11 induces ferroptosis[52] and TRX has been shown to inhibit ferroptosis via a mechanism involving GPX4 activation.[52, 53] In agreement with these observations, we found that rhTRX increased expression of SLC7A11 and GPX4 in EML cells, and to an even greater degree in cancer cells (Figure7A,B). The gene discussed is TXN; the disease is cancer.