GPX4 and cancer: Inactivation of GPX4 or SLC7A11 induces ferroptosis[52] and TRX has been shown to inhibit ferroptosis via a mechanism involving GPX4 activation.[52, 53] In agreement with these observations, we found that rhTRX increased expression of SLC7A11 and GPX4 in EML cells, and to an even greater degree in cancer cells (Figure7A,B).