Ferroptosis, an intracellular iron‐dependent form of regulated cell death caused by lipid peroxidation and iron accumulation, plays an important role in the functional maintenance of murine HSPCs[47] and in the biological processes of cancer cells.[48, 49, 50] HSPCs have been reported to have low rates of protein synthesis that make them selectively vulnerable to ferroptosis.[51] The amino acid transporter SLC7A11 – glutathione peroxidase‐4 (GPX4) signaling axis constitutes the major cellular regulator of ferroptosis. Here, GPX4 is linked to cancer.