GPX4 and cancer: Ferroptosis plays an important role in the functional maintenance of HSPCs[47] and cancer cells, and while some cancer cells exhibit greater or lesser sensitivity to ferroptosis, it has been observed that cancer cells that are resistant to apoptosis are exquisitely vulnerable to ferroptosis.[48, 50] The differential effect of TRX and ORP100S on cancer cells is intriguing and unlikely to be due to the initially high levels of GPX4 and SLC7A11 observed in some cancer cells and tumors.