ORP100 treatment likewise suppressed chemotherapy‐induced GPX4 and SLC7A11 downregulation in vivo in BM cells but not in tumors when evaluated in an EG7‐implanted tumor model treated with 5‐FU (Figure 7H) or in a B16‐F10 tumor‐implantation model treated with cisplatin (Figure 7I). Here, SLC7A11 is linked to neoplasm.