The overall role of TRX in p53‐mediated stress responses is likely complex, as TRX has been shown to modulate downstream p53 trans‐activation functions post‐transcriptionally via enhancement of sequence‐specific DNA binding, in contrast to the upstream ability of TRX but not ORP100S to down‐regulate p53 expression transcriptionally in cancer cells as demonstrated here. Here, TP53 is linked to cancer.