To further understand the role of p53 in chemotherapy‐induced ferroptosis, human colon cancer cells with or without functional p53 mutations were compared.[57] Exposure to chemotherapeutic agents induced ferroptosis in SW48 cells (p53 wildtype) but not in LS1034 cells (p53 mutant: exon 7 codon 245 G to A nucleotide substitution, resulting in Gly to Ser mutation),[57] and this induction was reversible by rhTRX but not ORP100S (Figure 8B,C; Figure S14, Supporting Information). Here, TP53 is linked to colonic neoplasm.