In patients who had experienced an acute myocardial infarction, recombinant MMP‐2 induced the shedding of membrane‐bound CD100 from CD8+ T cells and the generation of soluble CD100, resulting in an elevation of CD8+ T‐cell cytotoxicity toward vascular endothelial cells [44]. The gene discussed is SEMA4D; the disease is acute myocardial infarction.