Cardiac membrane SGLT1 and total phosphorylated (p-SGLT1) protein was upregulated in a human subjects with type 2 diabetes (n = 3/group) and b db/db (n = 4/group) and c high fat diet (HFD) (n = 3/group) mouse models of type 2 diabetes. This evidence concerns the gene SLC5A1 and type 2 diabetes mellitus.