SLC5A1 and myocardial ischemia: Recently, we determined that SGLT1 is upregulated during cardiac ischemia/reperfusion (I/R) by activation of the transcription factors Sp1 and HNF-1 and the mRNA binding protein HuR, and that SGLT1 contributes to I/R injury by interacting with epidermal growth factor receptor (EGFR), which in turn increases protein kinase C (PKC), nicotinamide adenine dinucleotide phosphate oxidase 2 (Nox2) activity, and production of reactive oxygen species (ROS) [24].