SLC5A1 and type 2 diabetes mellitus: Phosphorylated and membrane-bound cardiac SGLT1 protein were increased approximately 50% in human subjects with type 2 diabetes (Fig. 2A), and total cardiac SGLT1 protein was increased approximately 400% in db/db mice at age 24 weeks (Fig. 2B) and approximately 100% in WT FVB/N mice fed a high fat diet (HFD) for 20 weeks beginning at age 8 weeks (Fig. 2C).