In contrast, MNX1-OE DEGs specific to 216 hr showed enrichment in myeloid progenitor/MLP-enriched cluster 8 which captures 192/216 hr haemGx cells, but diverges from MNX1-r infAML signatures (Figure 5—figure supplement 2B and C), instead approximating the distinct myelo-monocytic and/or mixed-lineage affiliation of KMT2A-rearranged AML, which is also common in older pediatric and adult patients. This evidence concerns the gene MNX1 and acute myeloid leukemia.