Interestingly, clusters of genes up-regulated in the mouse MNX1-OE leukemia (Figure 7—figure supplement 1D – k1, 2, 5, 6, and 9) do not robustly separate MNX1-r from other infAML by GSEA analysis (Figure 7—figure supplement 1E), and have diverged more from the patient data in their cell-type signature analysis than the original MNX1-OE cells in the FL (Figure 7—figure supplement 1F), putatively selecting a more generic program of leukemia transformation. Here, MNX1 is linked to leukemia.