By exploring the haemGx model through enforced expression of the MNX1 oncogene, which is a hallmark of infant AML harbouring the t(7;12) translocation, we identified the YS endothelial-to-hematopoietic transition as the transformation target of MNX1 gene rearrangement, shedding light on to its exclusive association with the infant age group. The gene discussed is MNX1; the disease is acute myeloid leukemia.