ICOS and neoplasm: LIGHT (Lymphotoxin-Like Inducible Protein 30 kDa), a member of the TNF superfamily, and ICOS (Inducible T-Cell Co-Stimulator), a T-cell co-stimulatory molecule, both show enhanced signaling, which may indicate a robust inflammatory response and immune cell activation within the RCC TME, which not only promotes the aggregation of immune cells but also helps tumor cells evade immune surveillance.