LIGHT (Lymphotoxin-Like Inducible Protein 30 kDa), a member of the TNF superfamily, and ICOS (Inducible T-Cell Co-Stimulator), a T-cell co-stimulatory molecule, both show enhanced signaling, which may indicate a robust inflammatory response and immune cell activation within the RCC TME, which not only promotes the aggregation of immune cells but also helps tumor cells evade immune surveillance. The gene discussed is TNFSF14; the disease is neoplasm.