CASC15 and colonic neoplasm: These cells exhibited copy number variation (CNV) and high expression of genes associated with proliferation, invasion, and metastasis.CASC15 has been shown to be abnormally highly expressed in various tumors and can affect tumor proliferation, invasion, and apoptosis.[36–38] Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease that plays an important role in tumor growth, invasion, and metastasis.[39–41] Previous studies have reported that the expression of KLK6 mRNA in colon cancer (CC) is significantly correlated with increased tumor stage and histological grade[42].