MCs play multiple roles in the tumor immune microenvironment, enhancing immune cell aggregation through the secretion of pro-inflammatory factors such as TNF (TNF+MC) and promoting tumor growth through the secretion of angiogenic factors (VEGFA+MC).[18–21] In our dataset, RCC was characterized by a decrease in TNF+ MCs and an increase in VEGFA+ MCs, suggestive of a shift toward pro-angiogenic and immunosuppressive functions. The gene discussed is TNF; the disease is neoplasm.