LRP5 and Osteoporosis - pseudoglioma: We and others have shown that mice (Kato et al., 2002; Holmen et al., 2004; Clément-Lacroix et al., 2005; Cong and Zhang, 2015) or rats (Ubels et al., 2022, 2020) lacking LRP5 develop skeletal and retinal defects similar to those seen in human OPPG patients.