The test for interaction only showed significant differences for glucose for both ABC and CERAD (p < 0.01) and for adenosine 5′‐diphosphoribose in purine metabolism (CERAD p = 0.02), both indicating stronger associations between those metabolites and AD‐related neuropathology markers among participants without an APOE ε4 allele. The gene discussed is APOE; the disease is Alzheimer disease.