APOE and Alzheimer disease: In total, 155 metabolic features were significantly associated with AD neuropathology markers after adjusting for age at death, race, sex, educational attainment, PMI, and APOE genotype and multiple testing (q values < 0.05), including 26, 17, and 20 metabolic features in HILIC column, and 64, 12, and 16 metabolic features in C18 column for ABC, Braak Stage, CERAD, respectively (Table 2).