The tau protein (short for ‘tubulin associated unit’) maintain the stability of microtubules in the axons of neurons [118], however, when hyperphosphorylation occurs, the microtubules disintegrate and the tau proteins form aggregates (neurofibrillary tangles, which are tangles of tau filaments) that are associated with neurodegenerative diseases [119,120]. The gene discussed is MAPT; the disease is neurodegenerative disease.