In recent years, researchers have conducted more and more large‐scale GWAS and Mendelian randomization analysis to explore the genetic variation related to diabetes nephropathy, including UMOD [17], COL4A3 [18], COL20A1 [19], TENM2 [20], SLC47A1 [21], and so forth. The gene discussed is COL4A3; the disease is diabetic kidney disease.