PSEN1 and Alzheimer disease: To determine the most suitable mouse model for investigating retromer dysfunction in AD, we analysed temporal expression patterns of key genes within the retromer interactome and its cargo across multiple transgenic AD models, including APP NL-F knock-in, APP NL-G-F knock-in, APP/PS1, 3xTgAD, and 5xFAD (Fig. 1A).