In several IDH1-mutant cancers, including intrahepatic cholangiocarcinoma (ICC), glioma, melanoma, chondrosarcoma, and prostate cancer, this includes the epigenetic repression of cGAS, a DNA sensor critical for activating the STING pathway and type I interferon signalling [104]. Here, STING1 is linked to intrahepatic cholangiocarcinoma.