Similarly, variants near GATA4 and members of the HOXB family of transcription factors such as HOXB7 have been associated with hypertension (Kichaev et al, 2019; Takeuchi et al, 2018), while HAND2 variants are associated with aortic dimension and atrial fibrillation (Pirruccello et al, 2022; Roselli et al, 2018). This evidence concerns the gene HAND2 and hypertensive disorder.