TGOLN2 and pancreatic adenocarcinoma: The TGN46 exits the TGN in ‘CARriers of the TGN to the cell Surface’ (CARTS), which play a role in transport of plasma membrane proteins (for example, desmoglein-I, a key component of desmosomes) and secretion (for example lysozyme C, pancreatic adenocarcinoma upregulated factor) and recycles back to the TGN via endosomes33–36.