For liver health, HbA1c lowering via GIPR/GLP1R was associated with reduced NAFLD (β = −0.34, [−0.50, −0.18], P = 2.74 × 10−5) and lower ALT levels (β = −0.26, [−0.38, −0.15], P = 8.39 × 10−6), with replication supporting these findings. This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.