Colocalization analyses further supported these findings, with strong evidence of colocalization in the GIPR locus between BMI lowering and T2D (PP.H4 = 0.754) and for the GLP1R locus between HbA1c lowering and T2D (PP.H4 = 0.996) (Table S13). Here, GLP1R is linked to type 2 diabetes mellitus.