HbA1c lowering by GIPR/GLP1R was associated with linked with lower NAFLD (β = −0.34, [−0.50, −0.18], P = 2.74 × 10−5), with consistent replication (β = −0.10, [−0.17, −0.04], P = 0.0028). Here, GIPR is linked to metabolic dysfunction-associated steatotic liver disease.