Independent MR further confirmed that binge drinking increases CAD risk (OR = 0.75, [0.67, 0.84], P = 1.26 × 10−6), reinforcing the significance of alcohol reduction in cardiovascular protection and mediation analyses showed that 12.6% (P = 0.023) of the GIPR/GLP1R relationship (Figure S10) and 12.2% (P = 0.048) of the GIPR impact on CAD risk were mediated through reductions in binge drinking (Table S10). Here, GIPR is linked to coronary artery disorder.