MR confirmed that BMI lowering via GIPR/GLP1R variants reduces CAD risk (OR = 0.36, [0.26, 0.51], P = 2.20 × 10−9) in addition to binge drinking frequency (Tables S9 & S10), suggesting a behavioral pathway contributing to cardiovascular benefits and aligning with previous MR work reporting this relationship [69]. Here, GIPR is linked to coronary artery disorder.