ITGA8 and cancer: For 13 of 34 MethSig cancer genes, including ITGA8 and CXCL5, we observed ubiquitous DNA hypermethylation across all regions together with nonubiquitous (that is, subclonal) CN loss (84 events of clonal hypermethylation with subclonal loss and 27 events of clonal CN loss with subclonal hypermethylation), whereas 8 of 20 canonical TSGs, including FAT1, exhibited ubiquitous CN loss with subclonal hypermethylation (28 events of clonal hypermethylation with subclonal loss and 38 events of clonal CN loss with subclonal hypermethylation).