Co-occurring CN loss and hypomethylation events were more prevalent in LUSC, affecting TSGs including NCOR1 (29 of 59 tumor regions), CDKN2C (28 of 59 tumor regions), CREBBP (26 of 59 tumor regions) and RPL22 (9 of 59 tumor regions) (Extended Data Fig. 6a). Here, NCOR1 is linked to neoplasm.