Unlike the MethSig cancer genes with an MR/MN smaller than 1, three of the 52 MethSig cancer genes with an MR/MN greater than 1 (CYP4F2, MSC and EIF5A2) were associated with worse survival in a multivariate Cox analysis (P = 0.022 for CYP4F2, P = 0.02 for MSC and P = 0.011 for EIF5A2; Fig. 4d and Supplementary Fig. 6e). Here, CYP4F2 is linked to cancer.