In our datasets, GRM8 showed expression specifically in SCLC and a few other tumour types (Extended Data Fig. 10h), a statistically significant enrichment of both non-synonymous mutations and more severe loss-of-function mutations (Extended Data Fig. 10i), and a significant number of piggyBac insertions (Extended Data Fig. 10j). The gene discussed is GRM8; the disease is small cell lung carcinoma.