To investigate the role of AKT in glycolysis inhibition, fresh APL blasts were treated with ATO 1 μM for 4 h, to downgrade PML::RARα [33], observing an increase in glycolysis, that was reversed by the addition of 1μM AKT inhibitor (Fig. 2B). Here, AKT1 is linked to acute promyelocytic leukemia.