PDHA1 and acute myeloid leukemia: Pyruvate dehydrogenase (PDHA1), involved in the synthesis of acetyl-CoA derived from glycolysis, to be used in TCA, is unchanged in these cells: PDHA1 mRNA (APL: 0.7 ± 0.5, n = 11; AML 0.9 ± 0.4, n = 43, p = 0.04) (Supplementary Fig. S4A); PDHA1 protein (APL: 0.6 ± 0.4, n = 11; AML 0.7 ± 0.3, n = 43, p = 0.4) (Supplementary Fig. S4B); PDHA1 protein (PR9 1.2 ± 0.2; MT cells 1.2 ± 0.7, p = 0.9) (Supplementary Fig. S4C).