BDNF and early-onset autosomal dominant Alzheimer disease: We have previously reported that DAO, as an alternative pathway to MAOB, can produce GABA24,55 and that MAOB-dependent astrocytic H2O2 causes reactive astrogliosis in animal models of Alzheimer’s disease.55 Therefore, it is possible that MAOB might be dominantly expressed and active over DAO in most cases of SCI, whereas in other cases, DAO might be dominant over MAOB and continue to produce H2O2 to enhance reactive astrogliosis and GABA to inhibit proBDNF even in the presence of KDS2010.