SLC38A6 and essential thrombocythemia: Notably, Slc38a6+/- mice displayed ET-like tremors (Supplementary Videos 8 and 9) and exhibited significant morphological, electrophysiological and molecular alterations similar to those of Slc38a6-/- mice (Supplementary Notes and Supplementary Fig. 10a–k), possibly due to the transcriptional repression of Slc38a6 via the upregulation of ATF3.