At humane endpoint, which occurred around the age of 1 yr, ATase1 sTg mice displayed reduced body weight (Fig 1D), hair loss with skin lesions (Fig 1C), cardiomegaly (Fig 2A), splenomegaly (Fig 2A and B), adenomegaly (Fig 2B), systemic inflammation (Fig 2C), reduced bone density (Fig 2D), rectal prolapse, and modest sarcopenia (Table 1). Here, NAT8B is linked to sarcopenia.