When ATase1 was overexpressed at birth (ATase1 sTgOB), by removing doxycycline from the diet, about 75% of the double transgenic animals developed a progeria-like phenotype with delayed growth that was indistinguishable from the phenotype of ATase1 sTgOC mice (Fig 1B–D). This evidence concerns the gene NAT8B and progeroid syndrome.