Importantly, duplications involving 3q25.31 (harboring AT-1/SLC33A1) and 2p13.1 (harboring ATase1/NAT8B and ATase2/NAT8) are specifically associated with autism spectrum disorder with intellectual disability and progeria-like dysmorphism (see National Organization for Rare Disorders database; see also [Francke, 1978; Fineman et al, 1983; Fryns et al, 1989; Sawyer et al, 1994; Rizzu et al, 1997; Ounap et al, 2005; Krumm et al, 2013; Poultney et al, 2013; Krumm et al, 2015]). The gene discussed is NAT8; the disease is autism spectrum disorder.