SLC33A1 and Spastic paraplegia: Indeed, mice knock-in for a loss-of-function AT-1 mutation associated with spastic paraplegia developed a peripheral form of neuropathy (Peng et al, 2014; Liu et al, 2017), mice with neuron-specific overexpression of AT-1 developed an autistic-like phenotype (Hullinger et al, 2016), and mice with systemic overexpression of AT-1 developed a progeria-like phenotype with reduced lifespan (Peng et al, 2018).