IGLON5 and tauopathy: We have previously shown that in monogenetic tauopathies (FTLD-MAPT) hyperexcitability may contribute to neurodegeneration [12] and in a study by Askin et al. hyperexcitability was seen in minutes to hours after anti-IgLON5 antibody-neuron contact and was able to induce tau pathology [19].