Emphasizing the anti-inflammatory effects of AT1R antagonism by losartan, which decreases inflammation and bone loss in the periodontal tissues of rats with experimentally induced periodontal disease, is important.6 Although slight immunostaining for AT1R and AT2R was observed in the cell cultures in the current study, the importance of such receptors cannot be disregarded in the whole animal because other cells of the periodontal tissue may interact to Ang II. This evidence concerns the gene AGTR1 and periodontal disorder.