CCNF and amyotrophic lateral sclerosis: CCNF is best known for targeting cell-cycle regulators for degradation, thereby allowing cells to progress through the S and G2 phases of their cell cycle.51,52,54,56 However, mutations in CCNF also cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD),57–60 two diseases that are characterized by ROS accumulation.61 It is possible that defective oxidative stress signaling, as described here, contributes to the emergence of ALS or FTD in patients with CCNF mutations.