Unlike this trend, some KRAB-ZNFs linked to cognitive disorders were human specifically upregulated, e.g., ZNF778, a candidate gene for autism spectrum disorder and cognitive impairment (Willemsen et al., 2010), and ZNF267, which is upregulated in the prefrontal cortex of AD patients (Patel et al., 2021). This evidence concerns the gene ZNF778 and Alzheimer disease.