ZNF267 and Cognitive impairment: Unlike this trend, some KRAB-ZNFs linked to cognitive disorders were human specifically upregulated, e.g., ZNF778, a candidate gene for autism spectrum disorder and cognitive impairment (Willemsen et al., 2010), and ZNF267, which is upregulated in the prefrontal cortex of AD patients (Patel et al., 2021).