For example, ZNF267, which was upregulated in the human cortex compared to NHPs (Figure 2F), is a clear transcriptomic signature for the diagnosis of AD (Fehlbaum-Beurdeley et al., 2012), and the expression of AluYa5 subfamily leads to genetic dysregulation in AD (Kim et al., 2016). The gene discussed is ZNF267; the disease is Alzheimer disease.