TNF and infection: The meta-analysis included 18 cohorts involving a total of 226 788 patients (30 869 treated with JAK inhibitors vs 195 919 treated with TNF antagonists), with 9369 case patients with serious infections.11,12,15,17,20,28,29,30,31,36,38,40,48,51,52 The IR of serious infections was 3.79 (95% CI, 2.85-5.05) per 100 person-years with JAK inhibitors vs 3.03 (95% CI, 2.32-3.95) per 100 person-years with TNF antagonists.