The dynamic interplay of inflammatory mediators, including interleukin (IL)-6, IL-10, and interferon (IFN)-γ, combined with serum biochemical parameters (C-reactive protein [CRP], ferritin, lactate dehydrogenase [LDH], and blood urea nitrogen [BUN]), has been well characterized as pathognomonic biomarkers for CRS severity stratification [10]. This evidence concerns the gene CRP and congenital rubella syndrome.