Notably, HAVCR1 demonstrated the most statistically significant association with kidney cancer risk (HR = 3.18, 95% confidence interval [CI]: 2.70–3.74, P = 1.11 × 10−40), followed by WFDC2 (HR = 2.22, 95% CI: 1.65–2.99, P = 3.58 × 10−4), IL10RB (HR = 2.41, 95% CI: 1.73–3.34, P = 4.66 × 10−4), IFNGR1 (HR = 3.25, 95% CI: 2.09–5.05, P = 4.86 × 10−4), DSC2 (HR = 2.44, 95% CI: 1.71–3.48, P = 3.00 × 10−3), and LTBR (HR = 2.68, 95% CI: 1.80–3.99, P = 3.93 × 10−3), in order of decreasing statistical significance. The gene discussed is DSC2; the disease is kidney cancer.