In the smoking analysis, 15 proteins demonstrated a significant PIE between smoking and kidney cancer, with mediation proportions ranging from 2.1% to 28.0%, excluding LAMP3 due to its significant interaction mediation effect (P < 0.05) (Supplemental Digital Content, Figure S4c, available at: http://links.lww.com/JS9/F77 and Supplemental Digital Content, Table S17, available at: http://links.lww.com/JS9/F77). Here, LAMP3 is linked to kidney cancer.