Of note, the thrombospondin (THBS1) gene, which plays important, well-established roles in hearing loss (Smeriglio et al., 2019), has extensive proximal HCMV-induced TEAD1-binding loss and HCMV-induced gene (Supplementary file 11) and protein level reduction (Figure 5E). This evidence concerns the gene TEAD1 and hearing loss disorder.