CCN2 and glaucoma: Additionally, the expression of key TEAD1 targets, including Connective Tissue Growth Factor (CTGF), Fibronectin (FN), α-smooth muscle actin (ACTA2), and Collagen 1a (COL1A) has all previously been found to be downregulated with HCMV infection of trabecular meshwork cells, leading to an increase in intra-ocular pressure, a leading cause of glaucoma (Choi et al., 2017).