Our secondary aim was to evaluate the significance of the balance between serum levels of cytokines that these Th cells produce (IFNG, IL2, and TNF for Th1; IL4, IL5, IL10, and IL13 for Th2) and cytokines that guide differentiation of Th1 (IFNG and IL12) and Th2 cells (IL4 and IL33) in colorectal cancer. The gene discussed is IL4; the disease is colorectal cancer.