FMR1 and fragile X syndrome: More recent findings indicate impairments in both sleep (Saré et al., 2017) and activity rhythms (Bonasera et al., 2017; Angelakos et al., 2019) in Fmr1 KO mice, all consistent with the sleep/wake disturbances reported in FXS individuals (Kronk et al., 2009; Kronk et al., 2010; Budimirovic et al., 2022).