Nevertheless, as previously reported for breast cancer with highly suspicious microcalcifications on mammography [52, 53], the mechanism regulating stage‐specific expression levels of CHDH/CHDH‐induced IL17RB and activation (phosphorylation) status of CREB1 should be further explored to provide a theoretical basis for CHDH as a diagnostic and therapeutic target for metastatic breast cancer. The gene discussed is CHDH; the disease is breast carcinoma.