One such bacterium is Fusobacterium nucleatum which is associated with adverse prognosis and recurrence after chemotherapy (using 5-fluorouracil and oxaliplatin) for colorectal cancer (CRC), which influences molecules such as TLR4 and MYD88, and triggers microRNAs and autophagy mechanisms (56, 202, 203). This evidence concerns the gene TLR4 and colorectal carcinoma.