To address this, OVs, notably T-VEC, Maraba virus, VacV and Ad-p53 have been engineered to deliver tumor-suppressor genes, which have been shown to induce hallmark features of ICD, including calreticulin exposure, ATP release, and high mobility group box 1 (HMGB1) secretion (8–10). This evidence concerns the gene HMGB1 and neoplasm.