Intriguingly, a mouse tumor model experiment indicated that anti-TIGIT antibody exerts significant anti-tumor effects combined with 3 × 8Gy radiation plus anti-PD-L1 treatment only, and no benefit was observed in anti-TIGIT antibody plus 2 × 12Gy radiation plus anti-PD-L1 treatment (9). This evidence concerns the gene CD274 and neoplasm.