NLRP3 and cryopyrin-associated periodic syndrome: In this study, we identified a case of adult-onset CAPS associated with a germline missense mutation at c.386A>G (p.Lys129Arg) in the NLRP3 (NM_001243133) gene in a previously healthy middle-aged Korean woman who presented with chronic, recurrent episodes of periorbital swelling, fever, rashes, and arthritis.