Furthermore, HDAC6, which acts as a histone acetylation “eraser,” lysine methyltransferase 2A (KMT2A), a methylation “writer,” and the bromodomain-containing BET family protein BRD4, an acetylation “reader,” each elevate PD-L1 immunoreactivity across melanomas, pancreatic carcinomas, and ovarian neoplasms. Here, KMT2A is linked to melanoma.