DUSP22 and Sepsis: When comparing methylation in neonates with LOS to neonates with EOS, 4 significantly hypomethylated gene promoters were noted- DUSP22, PM20D1, MIR10A, and MIR886. Pathway analysis revealed significant hypermethylation of regions involved in T-cell activation and T-cell differentiation, and hypomethylation of regions involved in neutrophil and mast cell activation when comparing neonates with sepsis to controls.