A recent cohort study using the Surveillance, Epidemiology, and End Results (SEER) Oncotype DX 2004–2015 database found that Black women in the United States were more likely to experience breast cancer–specific mortality from ER-positive, HER2-negative, axillary-node–negative breast cancer compared with non-Hispanic White women with similar Oncotype DX recurrence scores, even after adjusting for age, year of diagnosis, tumor size, progesterone receptor status, type of surgery, and administration of radiation therapy and chemotherapy [4]. The gene discussed is PGR; the disease is breast cancer.