The bronchial cut-off sign (OR = 4.55, 95%CI: 1.67-12.43, P = 0.003) and CEA (OR = 1.02, 95%CI: 1.00-1.04, P = 0.024) emerged as clinical risk factors for predicting LNM in lung adenocarcinoma. This evidence concerns the gene CEACAM5 and lung adenocarcinoma.