In patients with hormone receptor-positive and negative BC, the cumulative incidence of pregnancy at 10 years was 13.5% (65 out of 662 hormone receptor-positive patients) and 18.1% (50 out of 333 hormone receptor-negative patients), respectively (HR = 0.60, 95% CI: 0.41–0.87, P = 0.006) (Figure 2B). Here, NR4A1 is linked to breast cancer.