These disturbances may trigger oxidative stress, a microglial inflammatory response, amyloid-β deposition, and pathological Tau hyperphosphorylation in brain regions associated with cognition (Chakrabarty et al., 2022; Gaspar et al., 2016; Macauley et al., 2015; Sima et al., 2009; Tomlinson and Gardiner, 2008), thereby leading to neuronal damage and mitochondrial dysfunction, which ultimately results in cognitive decline in patients with PD. The gene discussed is MAPT; the disease is Mental deterioration.