In Ifnar1−/− mice, deletion of the conserved N154-X-S/T glycosylation motif in the ZIKV E protein completely abolished infection of dendritic cells expressing DC-SIGN or DC-SIGNR, demonstrating that E-glycan engagement of these C-type lectins is essential for viral entry into lectin-positive leukocytes (Carbaugh et al., 2019). The gene discussed is CLEC4M; the disease is infection.