Taken together, these results indicate that Doxy@CaCO3-PEG-activated Tet-HER1-CAR-T-cell therapy effectively eradicates F.n.-colonized tumors by concurrently killing F.n. and neutralizing tumor acidity to increase the tumor-infiltration and effector functions of activated Tet-HER1-CAR-T cells. This evidence concerns the gene EGFR and neoplasm.