Notably, we found that the treatment with two injections of Doxy@CaCO3-PEG and Tet-HER1-CAR-T cells exhibited more effective tumor suppression than that with two Doxy@CaCO3-PEG injections and one Tet-HER1-CAR-T cell injection, probably ascribed to the limited survival time of CAR-T cells after intravenous infusion [25]. Here, EGFR is linked to neoplasm.