To enable tumor-targeted delivery of Doxy for the tumor-localized activation of Tet-HER1-CAR-T cells, amorphous CaCO3 nanoparticles that are efficient at loading small molecules were synthesized, loaded with Doxy and coated with lipid bilayers to render their superior tumor-homing capacity according to our previously developed methods [22] (Fig. 1A). This evidence concerns the gene EGFR and neoplasm.