Moreover, the microcomputed tomography (micro-CT) results showed that the lung of mice treated with Doxy-activated Tet-HER1-CAR-T cells or conventional HER1-CAR-T cells exhibited markedly increased brightness on Day 10—a typical imaging feature of pneumonia (Fig. 5K)—which could be induced by high levels of pro-inflammatory cytokines [17]. Here, EGFR is linked to pneumonia.