Flow cytometry revealed that F.n. colonization significantly attenuated the tumor-infiltration efficacy of HER1-CAR-T cells but minimally disrupted the tumor-infiltration efficacy of both Doxy-activated and Doxy@CaCO3-PEG-activated Tet-HER1-CAR-T cells (Fig. 6M). Here, EGFR is linked to neoplasm.