EGFR and neoplasm: After that, by recording tumor growth curves and mouse survival rates (Fig. 4E), Doxy@CaCO3-PEG-activated Tet-HER1-CAR-T-cell therapy exhibited the most effective tumor-suppression effect and three of the five MDA-MB-468-tumor-bearing mice were fully cured without obvious tumor relapse within 63 days (Fig. 4F and G, and Fig. S15).