The GSAP was identified as a γ-secretase-interacting partner (Teranishi et al., 2010; Frykman et al., 2012), it could form a complex with γ-secretase and APP-CTF, and an SNP in GSAP has been discovered to be associated with Alzheimer’s disease, giving genetic evidence that links GSAP to AD susceptibility (He et al., 2010). Here, APP is linked to Alzheimer disease.