Administration of the dimerization of Lep9R3LC (diLep9R3LC) peptide and GSAP siRNA complexes in AD mice can reduce GSAP in the cortex/hippocampus, inhibit Aβ accumulation, reduce tau hyperphosphorylation, and improve cognitive function in AD mice (Kim et al., 2024). This evidence concerns the gene GSAP and Alzheimer disease.