There is evidence that the enzymatic activity of γ-secretase can also be influenced by interferon-induced transmembrane protein 3 (IFITM3), which is upregulated in tissue samples from certain late-onset Alzheimer’s disease patients and exhibits a positive correlation with γ-secretase activity (Hur et al., 2020). Here, IFITM3 is linked to early-onset autosomal dominant Alzheimer disease.