Transgenic mice with neuron-specific increases in TMP21 expression exhibit postnatal growth retardation and severe neurological issues like tremors, seizures, ataxia, uncoordinated movements, and premature death, complete deletion of TMP21 results in embryonic lethality at very early stages (Denzel et al., 2000; Gong et al., 2011). This evidence concerns the gene TMED10 and cerebellar ataxia.