APP and early-onset autosomal dominant Alzheimer disease: The GSAP was identified as a γ-secretase-interacting partner (Teranishi et al., 2010; Frykman et al., 2012), it could form a complex with γ-secretase and APP-CTF, and an SNP in GSAP has been discovered to be associated with Alzheimer’s disease, giving genetic evidence that links GSAP to AD susceptibility (He et al., 2010).