Although limited, current studies report an upregulation of HIF1A expression in PBMCs from patients with COVID-19 (Codo et al., 2020; Tian et al., 2021; Karabulut Uzunçakmak et al., 2022), and an association of HIF1A expression with viral replication (Duan et al., 2021). The gene discussed is HIF1A; the disease is COVID-19.