Regarding ventilatory support, we found that intubated patients exhibited increased expression of the metabolic gene SIRT1 (2.3-fold higher, 1.84 [0.7-7.1]) in NK cells from severe COVID-19 patients, compared to those receiving non-invasive ventilatory support (0.97 [0.2-2.8]), P = 0.039, see Figure 3B. This evidence concerns the gene SIRT1 and COVID-19.