The prevalence of PVs and LPVs in the LDLR, APOB, and PCSK9 genes ranges from 0.4% in the general population to 4.4% in patients with myocardial infarction (Zhou et al., 2024; Ramensky et al., 2021; Cui et al., 2019). The gene discussed is APOB; the disease is myocardial infarction.