Considering the sensitive and critical periods in the growth and development of adolescents, aerobic exercise not only stimulates the release of endorphins and activates the neuroendocrine system to alleviate pain and improve mood, but also increases hippocampal volume and promotes the secretion of brain-derived neurotrophic factor (BDNF), thus effectively alleviating symptoms of anxiety (Erickson et al., 2011). This evidence concerns the gene BDNF and Anxiety.