PCC occurs sporadically or within hereditary syndromes like von Hippel-Lindau disease (VHL), multiple endocrine neoplasia type 2 (MEN2), or neurofibromatosis type 1 (NF1), with mutations, particularly SDHB, increasing malignancy risk (2, 3). The gene discussed is NF1; the disease is von Hippel-Lindau disease.